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Who was studied 853 Chinese ancestry cases, 6,248 Chinese ancestry controls.
The effect
Each copy of the A allele carried 1.60 times the odds of Keratoconus (95% confidence interval 1.354-1.888); p = 3 × 10−8.
How common The A allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 8, band 8q13.3 — between genes, 0.2 kb from EYA1.
What each result means
A/ATwo copies of the version the research linked to Keratoconus. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Keratoconus. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Keratoconus. This is the starting point the study compared everyone against.
rs1077435 is a single position in the genome, in or near the near EYA1 gene. Published research associates it with keratoconus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1077435 linked to?
On MyGeneLog this position is linked to Keratoconus. The research behind each link, and its sources, are set out on that condition page.
Does having rs1077435 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1077435 come from?
GWAS Catalog, Investigative ophthalmology & visual science 2024, PMID:38767907. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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