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Who was studied 4,738 European ancestry female cases, 436,834 European ancestry female controls.
The effect
Each copy of the A allele carried 1.23 times the odds of Intrahepatic cholestasis of pregnancy (95% confidence interval 1.16-1.3); p = 2 × 10−13.
How common The A allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 12, band 12q24.31 — between genes, 3 kb from LRRC43.
What each result means
A/ATwo copies of the version the research linked to Intrahepatic cholestasis of pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Intrahepatic cholestasis of pregnancy. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Intrahepatic cholestasis of pregnancy. This is the starting point the study compared everyone against.
Nature communications · 2026 · PMID 42178310 · open access
Questions about rs10773287
What is rs10773287?
rs10773287 is a single position in the genome, in or near the near LRRC43 gene. Published research associates it with intrahepatic cholestasis of pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10773287 linked to?
On MyGeneLog this position is linked to Intrahepatic Cholestasis of Pregnancy. The research behind each link, and its sources, are set out on that condition page.
Does having rs10773287 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10773287 come from?
GWAS Catalog, Nature communications 2026, PMID:42178310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Intrahepatic cholestasis of pregnancy (rs10773287). MyGeneLog™. https://www.mygenelog.com/variants/rs10773287