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Vitiligo

CD44 · rs10768122

Where this position leads

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Vitiligo — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2012, PMID:22561518)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vitiligo. (GWAS Catalog, Nat Genet 2012, PMID:22561518)

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vitiligo compared to the general population. (GWAS Catalog, Nat Genet 2012, PMID:22561518)

Source

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

Jin Y, Birlea SA, Fain PR, Ferrara TM, Ben S, Riccardi SL, Cole JB, Gowan K, Holland PJ, Bennett DC, Luiten RM, Wolkerstorfer A

and 19 more — show all

van der Veen JP, Hartmann A, Eichner S, Schuler G, van Geel N, Lambert J, Kemp EH, Gawkrodger DJ, Weetman AP, Taïeb A, Jouary T, Ezzedine K, Wallace MR, McCormack WT, Picardo M, Leone G, Overbeck A, Silverberg NB, Spritz RA

Nature genetics · 2012 · PMID 22561518 · open access

Questions about rs10768122

What is rs10768122?

rs10768122 is a single position in the genome, in or near the CD44 gene. Published research associates it with vitiligo. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10768122 linked to?

On MyGeneLog this position is linked to Vitiligo. The research behind each link, and its sources, are set out on that condition page.

Does having rs10768122 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10768122 come from?

GWAS Catalog, Nat Genet 2012, PMID:22561518. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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