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Takes medication for gout?

BICC1 · rs10763558

Where this position leads

Condition: Gout

rs10763558 Condition: Gout Gout Condition rs10763558 rs10763558 BICC1

What the study found

Who was studied 4,708 African American or Afro-Caribbean cases, 50,797 African American or Afro-Caribbean controls, 1,396 Hispanic or Latin American cases, 27,918 Hispanic or Latin American controls, 573 East Asian ancestry cases, 2,974 East Asian ancestry controls, 20,817 European ancestry cases, 294,851 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0896 lower (95% confidence interval 0.072-0.107); p = 4 × 10−20.

How common The G allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 10, band 10q21.1 — in an intron of BICC1.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Takes medication for gout? compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Takes medication for gout?.
T/T Published research associates this genotype with typical/baseline likelihood of Takes medication for gout? — no copies of the reported risk allele.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs10763558

What is rs10763558?

rs10763558 is a single position in the genome, in or near the BICC1 gene. Published research associates it with takes medication for gout?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10763558 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs10763558 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10763558 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Takes medication for gout? (rs10763558). MyGeneLog™. https://www.mygenelog.com/variants/rs10763558

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