Sensitive

Breast cancer

LMX1B · rs10760444

Where this position leads

What the study found

Who was studied 24,206 East Asian ancestry cases, 24,775 East Asian ancestry controls, 122,977 European ancestry cases, 105,974 European ancestry controls; replicated in 10,829 East Asian ancestry cases, 10,996 East Asian ancestry controls, 5,958 Asian ancestry cases, 5,684 Asian ancestry controls.

The effect Each copy of the A allele carried 0.96 times the odds of Breast cancer (95% confidence interval 0.95-0.97); p = 8 × 10⁻¹⁴.

Where it sits Chromosome 9, band 9q33.3 — in an intron of LMX1B.

What each result means

A/A Two copies of the version the research linked to Breast cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Breast cancer. That is a smaller link than two copies.

G/G No copy of the version the research linked to Breast cancer. This is the starting point the study compared everyone against.

Source

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, Park SK, Bolla MK, Dennis J, Wang Q, Yang Y, Shi J

and 50 more — show all

Guo X, Li B, Tao R, Aronson KJ, Chan KYK, Chan TL, Gao YT, Hartman M, Kee Ho W, Ito H, Iwasaki M, Iwata H, John EM, Kasuga Y, Soon Khoo U, Kim MK, Kong SY, Kurian AW, Kwong A, Lee ES, Li J, Lophatananon A, Low SK, Mariapun S, Matsuda K, Matsuo K, Muir K, Noh DY, Park B, Park MH, Shen CY, Shin MH, Spinelli JJ, Takahashi A, Tseng C, Tsugane S, Wu AH, Xiang YB, Yamaji T, Zheng Y, Milne RL, Dunning AM, Pharoah PDP, García-Closas M, Teo SH, Shu XO, Kang D, Easton DF, Simard J, Zheng W

Nature communications · 2020 · PMID 32139696 · open access

Questions about rs10760444

What is rs10760444?

rs10760444 is a single position in the genome, in or near the LMX1B gene. Published research associates it with breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10760444 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs10760444 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10760444 come from?

GWAS Catalog, Nature communications 2020, PMID:32139696. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Breast cancer (rs10760444). MyGeneLog™. https://www.mygenelog.com/variants/rs10760444

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