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Morningness

PTPRD · rs10758971

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁷, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 434,835 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.012 higher (95% confidence interval 0.0081-0.0159); p = 5 × 10⁻⁸.

How common The T allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 9, band 9p24.1 — in an intron of PTPRD.

What each result means

C/C No copy of the version the research linked to Morningness. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Morningness. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Morningness. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H

and 12 more — show all

White T, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D

23andMe Research Team

Nature genetics · 2019 · PMID 30804565

Questions about rs10758971

What is rs10758971?

rs10758971 is a single position in the genome, in or near the PTPRD gene. Published research associates it with morningness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10758971 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10758971 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Morningness (rs10758971). MyGeneLog™. https://www.mygenelog.com/variants/rs10758971

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