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Peripheral artery disease in ever smokers

CDKN2B-AS1 · rs10757272

Where this position leads

Condition: Peripheral Artery Disease

rs10757272 Condition: Peripheral Artery Disease Peripheral Artery Disease Condition rs10757272 rs10757272 CDKN2B-AS1

What the study found

Who was studied 7,404 Finnish ancestry cases, 205,693 Finnish ancestry controls, 7,404 non-Scandinavian ancestry cases, 205,693 non-Scandinavian ancestry controls, 7,404 British ancestry cases, 205,693 British ancestry controls.

The effect Each copy of the T allele carried 1.15 times the odds of Peripheral artery disease in ever smokers (95% confidence interval 1.11-1.2); p = 1 × 10−13.

How common The T allele had a frequency of about 46% in the people studied.

Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2B-AS1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Peripheral artery disease in ever smokers — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Peripheral artery disease in ever smokers.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Peripheral artery disease in ever smokers compared to the general population.
Source
Genome-Wide Association Study of Peripheral Artery Disease
van Zuydam NR, Stiby A, Abdalla M, Austin E, Dahlström EH, Dahlström EH, McLachlan S, Vlachopoulou E, Ahlqvist E, Di Liao C, Sandholm N, Forsblom C
and 21 more — show all
Mahajan A, Robertson NR, Rayner NW, Lindholm E, Sinisalo J, Perola M, Kallio M, Weiss E, Price J, Paterson A, Klein B, Salomaa V, Palmer CNA, Groop PH, Groop L, McCarthy MI, de Andrade M, Morris AP, Hopewell JC, Colhoun HM, Kullo IJ
GoLEAD Consortium, SUMMIT Consortium†
Circulation. Genomic and precision medicine · 2021 · PMID 34601942 · open access

Questions about rs10757272

What is rs10757272?

rs10757272 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with peripheral artery disease in ever smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10757272 linked to?

On MyGeneLog this position is linked to Peripheral Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs10757272 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10757272 come from?

GWAS Catalog, Circulation. Genomic and precision medicine 2021, PMID:34601942. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Peripheral artery disease in ever smokers (rs10757272). MyGeneLog™. https://www.mygenelog.com/variants/rs10757272

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