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Hip minimal joint space width

FANCC · rs10739993

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 50,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.04 lower (95% confidence interval 0.02-0.06); p = 2 × 10⁻⁸.

How common The T allele had a frequency of about 59% in the people studied.

Where it sits Chromosome 9, band 9q22.32 — in an intron of FANCC.

What each result means

C/C No copy of the version the research linked to Hip minimal joint space width. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Hip minimal joint space width. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Hip minimal joint space width. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses

Faber BG, Frysz M, Boer CG, Evans DS, Ebsim R, Flynn KA, Lundberg M, Southam L, Hartley A, Saunders FR, Lindner C, Gregory JS

and 10 more — show all

Aspden RM, Lane NE, Harvey NC, Evans DM, Zeggini E, Davey Smith G, Cootes T, Van Meurs J, Kemp JP, Tobias JH

EBioMedicine · 2023 · PMID 37619450 · open access

Questions about rs10739993

What is rs10739993?

rs10739993 is a single position in the genome, in or near the FANCC gene. Published research associates it with hip minimal joint space width. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10739993 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10739993 come from?

GWAS Catalog, EBioMedicine 2023, PMID:37619450. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hip minimal joint space width (rs10739993). MyGeneLog™. https://www.mygenelog.com/variants/rs10739993

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