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Who was studied 5,791 African ancestry cases, 20,883 African ancestry controls, 1,170 admixed ancestry cases, 13,217 admixed ancestry controls, 12,665 East Asian ancestry cases, 245,263 East Asian ancestry controls, 95,524 European ancestry cases, 1,270,968 European ancestry controls; replicated in 48,886 European ancestry cases, 279,185 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.0305 lower (95% confidence interval 0.022-0.039); p = 2 × 10−12.
How common The G allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 9, band 9p21.3 — in an intron of CDKN2B-AS1.
What each result means
A/ANo copy of the version the research linked to Heart failure. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Heart failure. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Heart failure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 36376295 · open access
Questions about rs10738604
What is rs10738604?
rs10738604 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10738604 linked to?
On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.
Does having rs10738604 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10738604 come from?
GWAS Catalog, Nature communications 2022, PMID:36376295. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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