Gene Knowledge Graph
UTC
Standard

Highest math class taken (MTAG)

H2BC5 · rs1059490

Where this position leads

Condition: Educational Attainment

rs1059490 Condition: Educational Attainment Educational Attainment Condition rs1059490 rs1059490 H2BC5

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Highest math class taken (MTAG) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Highest math class taken (MTAG).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Highest math class taken (MTAG) compared to the general population.
Source
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linnér R, Fontana MA, Kundu T
and 65 more — show all
Lee C, Li H, Li R, Royer R, Timshel PN, Walters RK, Willoughby EA, Yengo L, Alver M, Bao Y, Clark DW, Day FR, Furlotte NA, Joshi PK, Kemper KE, Kleinman A, Langenberg C, Mägi R, Trampush JW, Verma SS, Wu Y, Lam M, Zhao JH, Zheng Z, Boardman JD, Campbell H, Freese J, Harris KM, Hayward C, Herd P, Kumari M, Lencz T, Luan J, Malhotra AK, Metspalu A, Milani L, Ong KK, Perry JRB, Porteous DJ, Ritchie MD, Smart MC, Smith BH, Tung JY, Wareham NJ, Wilson JF, Beauchamp JP, Conley DC, Esko T, Lehrer SF, Magnusson PKE, Oskarsson S, Pers TH, Robinson MR, Thom K, Watson C, Chabris CF, Meyer MN, Laibson DI, Yang J, Johannesson M, Koellinger PD, Turley P, Visscher PM, Benjamin DJ, Cesarini D
23andMe Research Team · COGENT (Cognitive Genomics Consortium) · Social Science Genetic Association Consortium
Nature genetics · 2018 · PMID 30038396

Questions about rs1059490

What is rs1059490?

rs1059490 is a single position in the genome, in or near the H2BC5 gene. Published research associates it with highest math class taken (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1059490 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does having rs1059490 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1059490 come from?

GWAS Catalog, Nat Genet 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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