UPK3A · rs1057356
Where this position leads
Condition: Height
What the study found
Who was studied 405,540 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.00856 lower (95% confidence interval 0.0059-0.0112); p = 2 × 10−10.
How common The A allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 22, band 22q13.31 — a synonymous change in UPK3A.
What ClinVar records
Classification
Benign for Renal hypodysplasia/aplasia 1; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2024-11-28.
ClinVar record 341987 NM_006953.4(UPK3A):c.858A>G (p.Gln286=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs1057356 is a single position in the genome, in or near the UPK3A gene. Published research associates it with height (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Height (baseline) (rs1057356). MyGeneLog™. https://www.mygenelog.com/variants/rs1057356