Standard
White matter hyperintensity burden
TRIM47 · rs1055129
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of White matter hyperintensity burden — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with White matter hyperintensity burden.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of White matter hyperintensity burden compared to the general population.
Source
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium
Fornage M,
Debette S,
Bis JC,
Schmidt H,
Ikram MA,
Dufouil C,
Sigurdsson S,
Lumley T,
DeStefano AL,
Fazekas F,
Vrooman HA,
Shibata DK
and 51 more — show all
Maillard P,
Zijdenbos A,
Smith AV,
Gudnason H,
de Boer R,
Cushman M,
Mazoyer B,
Heiss G,
Vernooij MW,
Enzinger C,
Glazer NL,
Beiser A,
Knopman DS,
Cavalieri M,
Niessen WJ,
Harris TB,
Petrovic K,
Lopez OL,
Au R,
Lambert JC,
Hofman A,
Gottesman RF,
Garcia M,
Heckbert SR,
Atwood LD,
Catellier DJ,
Uitterlinden AG,
Yang Q,
Smith NL,
Aspelund T,
Romero JR,
Rice K,
Taylor KD,
Nalls MA,
Rotter JI,
Sharrett R,
van Duijn CM,
Amouyel P,
Wolf PA,
Gudnason V,
van der Lugt A,
Boerwinkle E,
Psaty BM,
Seshadri S,
Tzourio C,
Breteler MM,
Mosley TH,
Schmidt R,
Longstreth WT,
DeCarli C,
Launer LJ
Annals of neurology · 2011 · PMID 21681796
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs1055129
What is rs1055129?
rs1055129 is a single position in the genome, in or near the TRIM47 gene. Published research associates it with white matter hyperintensity burden. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs1055129?
Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1055129 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1055129 come from?
GWAS Catalog, Ann Neurol 2011, PMID:21681796. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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