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Phospholipids in medium HDL

RRBP1 · rs1054787

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻³⁵, with 13 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the C allele shifted the measure 0.03 mmol/L lower (95% confidence interval 0.03-0.03); p = 3 × 10⁻²³.

Where it sits Chromosome 20, band 20p12.1 — in an intron of RRBP1.

How common each version is

CG

Korean KRGDB

C 49.7% · G 50.3%

Korean Korea4K

C 51.3% · G 48.7%

Japanese ToMMo

C 54.3% · G 45.7%

Vietnamese

C 48.6% · G 51.4%

World gnomAD

C 14.3% · G 85.7%

World 1000 Genomes

C 23.4% · G 76.6%

World TOPMed

C 14.1% · G 85.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Phospholipids in medium HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Phospholipids in medium HDL. That is a smaller link than two copies.

G/G No copy of the version the research linked to Phospholipids in medium HDL. This is the starting point the study compared everyone against.

Source

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C

Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs1054787

What is rs1054787?

rs1054787 is a single position in the genome, in or near the RRBP1 gene. Published research associates it with phospholipids in medium hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1054787 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs1054787 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1054787 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Phospholipids in medium HDL (rs1054787). MyGeneLog™. https://www.mygenelog.com/variants/rs1054787

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