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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,495,159 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.017 SD unit higher (95% confidence interval 0.012-0.022); p = 2 × 10−10.
How common The T allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 4, band 4q28.2 — in an intron of C4orf33.
What each result means
C/CNo copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Refractive error. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42009823 · open access
Questions about rs10518544
What is rs10518544?
rs10518544 is a single position in the genome, in or near the C4orf33 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10518544 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10518544 come from?
GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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