Sensitive

Type 1 diabetes

near RBPJ · rs10517086

Where this position leads

What the study found

Who was studied 7,514 European ancestry cases, 9,045 European ancestry controls; replicated in 4,267 European ancestry cases, 4,670 European ancestry controls, 4,342 European ancestry trios from 2,319 families.

The effect Each copy of the A allele carried 1.09 times the odds of Type 1 diabetes (95% confidence interval 1.02-1.17); p = 5 × 10⁻¹⁰.

How common The A allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 4, band 4p15.2 — in an intron of LINC02357.

What each result means

A/A Two copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.

G/G No copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.

Source

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F

and 6 more — show all

Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS

Type 1 Diabetes Genetics Consortium

Nature genetics · 2009 · PMID 19430480 · open access

What people read about alongside this

Blood sugar and insulin1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10517086

What is rs10517086?

rs10517086 is a single position in the genome, in or near the near RBPJ gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10517086 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10517086?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10517086 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10517086 come from?

GWAS Catalog, Nat Genet 2009, PMID:19430480. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 1 diabetes (rs10517086). MyGeneLog™. https://www.mygenelog.com/variants/rs10517086

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