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Its strongest genetic-study result is p = 10−12, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 343,836 European ancestry individuals, 129,405 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0233 higher (95% confidence interval 0.017-0.03); p = 2 × 10−12.
Where it sits Chromosome 3, band 3q26.2 — in an intron of SLC2A2.
What each result means
A/ATwo copies of the version the research linked to Serum uric acid levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Serum uric acid levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Serum uric acid levels. This is the starting point the study compared everyone against.
rs10513688 is a single position in the genome, in or near the SLC2A2 gene. Published research associates it with serum uric acid levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs10513688 affect how medicines work?
SLC2A2 carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs10513688 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10513688 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license