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Cerebrospinal fluid protein TNFRSF6B levels

near ZIC4 · rs10513309

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,524 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.158 higher (95% confidence interval 0.12-0.2); p = 2 × 10⁻¹³.

How common The C allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 3, band 3q24 — between genes, 49 kb from ZIC4.

What each result means

C/C Two copies of the version the research linked to Cerebrospinal fluid protein TNFRSF6B levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Cerebrospinal fluid protein TNFRSF6B levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Cerebrospinal fluid protein TNFRSF6B levels. This is the starting point the study compared everyone against.

Source

Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease

Western D, Yang C, Timsina J, Liu M, Wang C, Campbell MC, Kotzbauer P, Perlmutter JS, Schindler SE, Morris JC, Holtzman DM, Alvarez I

and 12 more — show all

Pastor P, Wyss-Coray T, Marquié M, Cano A, Sung YJ, de Rojas I, Ruiz A, Budde J, Fernandez MV, Tarawneh R, Ibanez L, Cruchaga C

Science translational medicine · 2026 · PMID 42054495

Questions about rs10513309

What is rs10513309?

rs10513309 is a single position in the genome, in or near the near ZIC4 gene. Published research associates it with cerebrospinal fluid protein tnfrsf6b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10513309 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10513309 come from?

GWAS Catalog, Science translational medicine 2026, PMID:42054495. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebrospinal fluid protein TNFRSF6B levels (rs10513309). MyGeneLog™. https://www.mygenelog.com/variants/rs10513309

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