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Neuroticism

PTCH1 · rs10512249

Where this position leads

Condition: Neuroticism

rs10512249 Condition: Neuroticism Neuroticism Condition rs10512249 rs10512249 PTCH1

What the study found

Who was studied 523,783 European ancestry individuals; replicated in 59,206 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0187 higher (95% confidence interval 0.014-0.024); p = 4 × 10−13.

How common The A allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 9, band 9q22.32 — in an intron of PTCH1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroticism compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroticism.
G/G Published research associates this genotype with typical/baseline likelihood of Neuroticism — no copies of the reported risk allele.
Source
Multivariate genome-wide analyses of the well-being spectrum
Baselmans BML, Jansen R, Ip HF, van Dongen J, Abdellaoui A, van de Weijer MP, Bao Y, Smart M, Kumari M, Willemsen G, Hottenga JJ, Boomsma DI
and 3 more — show all
de Geus EJC, Nivard MG, Bartels M
BIOS consortium · Social Science Genetic Association Consortium
Nature genetics · 2019 · PMID 30643256

Questions about rs10512249

What is rs10512249?

rs10512249 is a single position in the genome, in or near the PTCH1 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10512249 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs10512249 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10512249 come from?

GWAS Catalog, Nat Genet 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs10512249). MyGeneLog™. https://www.mygenelog.com/variants/rs10512249

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