Sensitive

Gastric cancer

PLCE1 · rs10509670

Where this position leads

Condition: Non-Cardia Gastric Cancer

rs10509670 Condition: Non-Cardia Gastric Cancer Non-Cardia Gastric Cancer Condition rs10509670 rs10509670 PLCE1

What the study found

Who was studied 1,015 Han Chinese ancestry cases, 4,541 Han Chinese ancestry controls; replicated in 2,350 Chinese ancestry cases, 2,708 Chinese ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 2 × 10−18.

Where it sits Chromosome 10, band 10q23.33 — in an intron of PLCE1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Gastric cancer — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gastric cancer.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gastric cancer compared to the general population.
Source

Questions about rs10509670

What is rs10509670?

rs10509670 is a single position in the genome, in or near the PLCE1 gene. Published research associates it with gastric cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10509670 linked to?

On MyGeneLog this position is linked to Non-Cardia Gastric Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs10509670 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10509670 come from?

GWAS Catalog, Science bulletin 2026, PMID:41963194. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Gastric cancer (rs10509670). MyGeneLog™. https://www.mygenelog.com/variants/rs10509670

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