Sensitive

Response to tamoxifen in breast cancer

C10orf11 · rs10509373

Where this position leads

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Response to tamoxifen in breast cancer compared to the general population. (GWAS Catalog, Hum Mol Genet 2011, PMID:22180457)

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Response to tamoxifen in breast cancer. (GWAS Catalog, Hum Mol Genet 2011, PMID:22180457)

T/T Published research associates this genotype with typical/baseline likelihood of Response to tamoxifen in breast cancer — no copies of the reported risk allele. (GWAS Catalog, Hum Mol Genet 2011, PMID:22180457)

Source

A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese

Kiyotani K, Mushiroda T, Tsunoda T, Morizono T, Hosono N, Kubo M, Tanigawara Y, Imamura CK, Flockhart DA, Aki F, Hirata K, Takatsuka Y

and 6 more — show all

Okazaki M, Ohsumi S, Yamakawa T, Sasa M, Nakamura Y, Zembutsu H

Human molecular genetics · 2012 · PMID 22180457

Questions about rs10509373

What is rs10509373?

rs10509373 is a single position in the genome, in or near the C10orf11 gene. Published research associates it with response to tamoxifen in breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10509373 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs10509373 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10509373 come from?

GWAS Catalog, Hum Mol Genet 2011, PMID:22180457. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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