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Uterine fibroids

ZEB1 · rs10508765

Where this position leads

Condition: Uterine Fibroids

rs10508765 Condition: Uterine Fibroids Uterine Fibroids Condition rs10508765 rs10508765 ZEB1

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Uterine fibroids compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Uterine fibroids.
G/G Published research associates this genotype with typical/baseline likelihood of Uterine fibroids — no copies of the reported risk allele.
Source
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
Gallagher CS, Mäkinen N, Harris HR, Rahmioglu N, Uimari O, Cook JP, Shigesi N, Ferreira T, Velez-Edwards DR, Edwards TL, Mortlock S, Ruhioglu Z
and 24 more — show all
Day F, Becker CM, Karhunen V, Martikainen H, Järvelin MR, Cantor RM, Ridker PM, Terry KL, Buring JE, Gordon SD, Medland SE, Montgomery GW, Nyholt DR, Hinds DA, Tung JY, Perry JRB, Lind PA, Painter JN, Martin NG, Morris AP, Chasman DI, Missmer SA, Zondervan KT, Morton CC
23andMe Research Team
Nature communications · 2019 · PMID 31649266 · open access

Questions about rs10508765

What is rs10508765?

rs10508765 is a single position in the genome, in or near the ZEB1 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10508765 linked to?

On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.

Does having rs10508765 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10508765 come from?

GWAS Catalog, Nat Commun 2019, PMID:31649266. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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