0 725Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 1,200 East Asian ancestry female cases, 60,614 East Asian ancestry female controls, 16,078 European ancestry female cases, 228,566 European ancestry female controls; replicated in 718 European ancestry female cases, 1,206 European ancestry female controls, 100 Central Asian ancestry female cases, 489 Central Asian ancestry female controls, 22 Asian ancestry female cases, 9 Asian ancestry female controls.
The effect
Each copy of the T allele carried 0.92 times the odds of Endometrial cancer (95% confidence interval 0.89-0.94); p = 5 × 10−9.
How common The T allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 8, band 8q24.21 — between genes, 15.5 kb from PVT1.
What each result means
C/CNo copy of the version the research linked to Endometrial cancer. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Endometrial cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Endometrial cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs10505508 is a single position in the genome, in or near the near PVT1 gene. Published research associates it with endometrial cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10505508 linked to?
On MyGeneLog this position is linked to Endometrial Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs10505508 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10505508 come from?
GWAS Catalog, EBioMedicine 2025, PMID:40633141. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 725Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Endometrial cancer (rs10505508). MyGeneLog™. https://www.mygenelog.com/variants/rs10505508