2 81214Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple1Others4Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 7,921 East Asian ancestry cases, 159,201 East Asian ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.111 lower (95% confidence interval 0.077-0.145); p = 2 × 10−10.
How common The T allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — a missense change in HLA-C.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Gastric cancer — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gastric cancer.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gastric cancer compared to the general population.
rs1050437 is a single position in the genome, in or near the HLA-C gene. Published research associates it with gastric cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1050437 linked to?
On MyGeneLog this position is linked to Non-Cardia Gastric Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs1050437 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1050437 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 81214Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple1Others4Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Gastric cancer (rs1050437). MyGeneLog™. https://www.mygenelog.com/variants/rs1050437