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Who was studied 206 East Asian ancestry cases, 172,289 East Asian ancestry controls.
The effect
Each copy of the G allele shifted the measure 3.19 higher (95% confidence interval 2.36-4.03); p = 6 × 10−14.
How common The G allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — a synonymous change in HLA-C.
What each result means
C/CNo copy of the version the research linked to Psoriasis vulgaris. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Psoriasis vulgaris. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Psoriasis vulgaris. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1050414 is a single position in the genome, in or near the HLA-C gene. Published research associates it with psoriasis vulgaris. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1050414 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1050414 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1050414 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 10127Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others7Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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