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Who was studied 86 European ancestry whole-genome sequenced cases, 4,280 European ancestry cases, 13,941 European ancestry whole-genome sequenced controls, 700,740 European ancestry controls.
The effect
Each copy of the C allele carried 1.14 times the odds of Nasal polyps (95% confidence interval 1.09-1.19); p = 1 × 10−8.
How common The C allele had a frequency of about 59% in the people studied.
Where it sits Chromosome 5, band 5q31.1 — a missense change in SLC22A4.
What ClinVar records
ClassificationBenign for SLC22A4 POLYMORPHISM; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-02-03.
ClinVar record 5750NM_003059.3(SLC22A4):c.1507C>T (p.Leu503Phe)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Nasal polyps. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Nasal polyps. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Nasal polyps. This is the starting point the study compared everyone against.
rs1050152 is a single position in the genome, in or near the SLC22A4 gene. Published research associates it with nasal polyps. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1050152 linked to?
On MyGeneLog this position is linked to Chronic Rhinosinusitis and the Bitter Taste Receptor. The research behind each link, and its sources, are set out on that condition page.
Does having rs1050152 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1050152 come from?
GWAS Catalog, Nat Genet 2019, PMID:30643255. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 3024123216Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity2Meta AI4Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others16Total30Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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