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Who was studied 77,690 European ancestry cases, 1,167,040 European ancestry controls, 67,864 Japanese ancestry cases, 1,026,594 Japanese ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0432 higher (95% confidence interval 0.031-0.055); p = 7 × 10−13.
How common The A allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 11, band 11p15.2 — in an intron of SPON1.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Nature genetics · 2023 · PMID 36653681 · open access
Questions about rs10500790
What is rs10500790?
rs10500790 is a single position in the genome, in or near the SPON1 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10500790 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs10500790 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10500790 come from?
GWAS Catalog, Nature genetics 2023, PMID:36653681. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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