Sensitive
Alzheimer's disease (late onset)
SLC24A4 · rs10498633
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alzheimer's disease (late onset) compared to the general population.
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alzheimer's disease (late onset).
T/T
Published research associates this genotype with typical/baseline likelihood of Alzheimer's disease (late onset) — no copies of the reported risk allele.
Source
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Lambert JC,
Ibrahim-Verbaas CA,
Harold D,
Naj AC,
Sims R,
Bellenguez C,
DeStafano AL,
Bis JC,
Beecham GW,
Grenier-Boley B,
Russo G,
Thorton-Wells TA
and 160 more — show all
Jones N,
Smith AV,
Chouraki V,
Thomas C,
Ikram MA,
Zelenika D,
Vardarajan BN,
Kamatani Y,
Lin CF,
Gerrish A,
Gerrish A,
Schmidt H,
Kunkle B,
Dunstan ML,
Ruiz A,
Bihoreau MT,
Choi SH,
Reitz C,
Pasquier F,
Cruchaga C,
Craig D,
Amin N,
Berr C,
Lopez OL,
De Jager PL,
Deramecourt V,
Johnston JA,
Evans D,
Lovestone S,
Letenneur L,
Morón FJ,
Rubinsztein DC,
Eiriksdottir G,
Sleegers K,
Goate AM,
Fiévet N,
Huentelman MW,
Gill M,
Brown K,
Kamboh MI,
Keller L,
Barberger-Gateau P,
McGuiness B,
Larson EB,
Green R,
Myers AJ,
Dufouil C,
Todd S,
Wallon D,
Love S,
Rogaeva E,
Gallacher J,
St George-Hyslop P,
Clarimon J,
Lleo A,
Bayer A,
Tsuang DW,
Yu L,
Tsolaki M,
Bossù P,
Spalletta G,
Proitsi P,
Collinge J,
Sorbi S,
Sanchez-Garcia F,
Fox NC,
Hardy J,
Deniz Naranjo MC,
Bosco P,
Clarke R,
Brayne C,
Galimberti D,
Mancuso M,
Matthews F,
Moebus S,
Mecocci P,
Del Zompo M,
Maier W,
Hampel H,
Pilotto A,
Bullido M,
Panza F,
Caffarra P,
Nacmias B,
Gilbert JR,
Mayhaus M,
Lannefelt L,
Hakonarson H,
Pichler S,
Carrasquillo MM,
Ingelsson M,
Beekly D,
Alvarez V,
Zou F,
Valladares O,
Younkin SG,
Coto E,
Hamilton-Nelson KL,
Gu W,
Razquin C,
Pastor P,
Mateo I,
Owen MJ,
Faber KM,
Jonsson PV,
Combarros O,
O'Donovan MC,
Cantwell LB,
Soininen H,
Blacker D,
Mead S,
Mosley TH Jr,
Bennett DA,
Harris TB,
Fratiglioni L,
Holmes C,
de Bruijn RF,
Passmore P,
Montine TJ,
Bettens K,
Rotter JI,
Brice A,
Morgan K,
Foroud TM,
Kukull WA,
Hannequin D,
Powell JF,
Nalls MA,
Ritchie K,
Lunetta KL,
Kauwe JS,
Boerwinkle E,
Riemenschneider M,
Boada M,
Hiltuenen M,
Martin ER,
Schmidt R,
Rujescu D,
Wang LS,
Dartigues JF,
Mayeux R,
Tzourio C,
Hofman A,
Nöthen MM,
Graff C,
Psaty BM,
Jones L,
Haines JL,
Holmans PA,
Lathrop M,
Pericak-Vance MA,
Launer LJ,
Farrer LA,
van Duijn CM,
Van Broeckhoven C,
Moskvina V,
Seshadri S,
Williams J,
Schellenberg GD,
Amouyel P
Nature genetics · 2013 · PMID 24162737
Questions about rs10498633
What is rs10498633?
rs10498633 is a single position in the genome, in or near the SLC24A4 gene. Published research associates it with alzheimer's disease (late onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10498633 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10498633 come from?
GWAS Catalog, Nat Genet 2013, PMID:24162737. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants