Sensitive

Medication use (antithrombotic agents)

TEX41 · rs10496973

Where this position leads

Condition: Colon Polyp

rs10496973 Condition: Colon Polyp Colon Polyp Condition rs10496973 rs10496973 TEX41

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 54,220 East Asian ancestry cases, 124,506 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0701 lower (95% confidence interval 0.045-0.095); p = 3 × 10−8.

How common The A allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 2, band 2q22.3 — in an intron of TEX41.

What each result means

A/A Two copies of the version the research linked to Medication use (antithrombotic agents). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Medication use (antithrombotic agents). That is a smaller link than two copies.
G/G No copy of the version the research linked to Medication use (antithrombotic agents). This is the starting point the study compared everyone against.
Source

Questions about rs10496973

What is rs10496973?

rs10496973 is a single position in the genome, in or near the TEX41 gene. Published research associates it with medication use (antithrombotic agents). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10496973 linked to?

On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs10496973 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10496973 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Medication use (antithrombotic agents) (rs10496973). MyGeneLog™. https://www.mygenelog.com/variants/rs10496973

← See all variants