Sensitive

Crohn's disease

THADA · rs10495903

Where this position leads

Condition: Crohn's Disease

rs10495903 Condition: Crohn's Disease Crohn's Disease Condition rs10495903 rs10495903 THADA

What the study found

Who was studied 6,333 European ancestry cases, 15,056 European ancestry controls; replicated in 15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry trios.

The effect Each copy of the T allele carried 1.14 times the odds of Crohn's disease (95% confidence interval 1.09-1.20); p = 2 × 10−14.

How common The T allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 2, band 2p21 — in an intron of THADA.

What each result means

C/C No copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs10495903

What is rs10495903?

rs10495903 is a single position in the genome, in or near the THADA gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10495903 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs10495903 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10495903 come from?

GWAS Catalog, Nat Genet 2010, PMID:21102463. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Crohn's disease (rs10495903). MyGeneLog™. https://www.mygenelog.com/variants/rs10495903

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