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Right hippocampal volume

near TANK-AS1 · rs10490563

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 65,791 European ancestry, East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0384 lower (95% confidence interval 0.027-0.05); p = 3 × 10⁻¹⁰.

How common The A allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 2, band 2q24.2 — between genes, 38.6 kb from TANK-AS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Right hippocampal volume compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Right hippocampal volume.

G/G Published research associates this genotype with typical/baseline likelihood of Right hippocampal volume — no copies of the reported risk allele.

Source

Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Liu N, Zhang L, Tian T, Cheng J, Zhang B, Qiu S, Geng Z, Cui G, Zhang Q, Liao W, Yu Y, Zhang H

and 32 more — show all

Gao B, Xu X, Han T, Yao Z, Qin W, Liu F, Liang M, Xu Q, Fu J, Xu J, Zhu W, Zhang P, Li W, Shi D, Wang C, Lui S, Yan Z, Chen F, Li J, Zhang J, Wang D, Shen W, Miao Y, Xian J, Gao JH, Zhang X, Li MJ, Xu K, Zuo XN, Wang M, Ye Z, Yu C

CHIMGEN Consortium

Nature genetics · 2023 · PMID 37337106

Questions about rs10490563

What is rs10490563?

rs10490563 is a single position in the genome, in or near the near TANK-AS1 gene. Published research associates it with right hippocampal volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10490563 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10490563 come from?

GWAS Catalog, Nature genetics 2023, PMID:37337106. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Right hippocampal volume (rs10490563). MyGeneLog™. https://www.mygenelog.com/variants/rs10490563

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