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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 53,184 British ancestry cases, 373,611 British ancestry controls; replicated in 367,900 European ancestry cases, 363,919 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0275 lower (95% confidence interval 0.02-0.035); p = 2 × 10−14.
How common The T allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 2, band 2p22.1 — in an intron of SLC8A1.
What each result means
C/CNo copy of the version the research linked to Fracture. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Fracture. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Fracture. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2019 · PMID 30598549 · open access
Questions about rs10490045
What is rs10490045?
rs10490045 is a single position in the genome, in or near the SLC8A1 gene. Published research associates it with fracture. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10490045 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10490045 come from?
GWAS Catalog, Nature genetics 2019, PMID:30598549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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