Sensitive

Renal cell carcinoma

SAMD5 · rs10484683

Where this position leads

What the study found

Who was studied 3,227 European ancestry male cases, 4,916 European ancestry male controls; replicated in 2,261 European ancestry male cases, 5,852 European ancestry male controls.

The effect Each copy of the A allele carried 1.20 times the odds of Renal cell carcinoma (95% confidence interval 1.12-1.28); p = 2 × 10⁻⁸.

Where it sits Chromosome 6, band 6q24.3 — between genes, 93.4 kb from SAMD5.

What each result means

A/A Two copies of the version the research linked to Renal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Renal cell carcinoma. That is a smaller link than two copies.

G/G No copy of the version the research linked to Renal cell carcinoma. This is the starting point the study compared everyone against.

Source

Sex specific associations in genome wide association analysis of renal cell carcinoma

Laskar RS, Muller DC, Li P, Machiela MJ, Ye Y, Gaborieau V, Foll M, Hofmann JN, Colli L, Sampson JN, Wang Z, Bacq-Daian D

and 96 more — show all

Boland A, Abedi-Ardekani B, Durand G, Le Calvez-Kelm F, Robinot N, Blanche H, Prokhortchouk E, Skryabin KG, Burdett L, Yeager M, Radojevic-Skodric S, Savic S, Foretova L, Holcatova I, Janout V, Mates D, Rascu S, Mukeria A, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Świątkowska B, Benhamou S, Cancel-Tassin G, Cussenot O, Trichopoulou A, Riboli E, Overvad K, Panico S, Ljungberg B, Sitaram RT, Giles GG, Milne RL, Severi G, Bruinsma F, Fletcher T, Koppova K, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Pharoah P, Andreotti G, Beane Freeman LE, Koutros S, Albanes D, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Carol H, Freedman ML, Pomerantz MM, Cho E, Kraft P, Preston MA, Wilson KM, Michael Gaziano J, Sesso HD, Black A, Freedman ND, Huang WY, Anema JG, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Chow WH, Moore LE, Choueiri TK, Wood C, Johansson M, McKay JD, Brown KM, Rothman N, Lathrop MG, Deleuze JF, Wu X, Brennan P, Chanock SJ, Purdue MP, Scelo G

European journal of human genetics : EJHG · 2019 · PMID 31231134

Questions about rs10484683

What is rs10484683?

rs10484683 is a single position in the genome, in or near the SAMD5 gene. Published research associates it with renal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10484683 linked to?

On MyGeneLog this position is linked to Renal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs10484683 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10484683 come from?

GWAS Catalog, European journal of human genetics : EJHG 2019, PMID:31231134. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Renal cell carcinoma (rs10484683). MyGeneLog™. https://www.mygenelog.com/variants/rs10484683

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