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Varicella zoster virus glycoproteins E and I antibody levels

HLA-DQA1 · rs1048381

What the study found

Who was studied 7,595 White British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.22 lower (95% confidence interval 0.18-0.26); p = 6 × 10−25.

Where it sits Chromosome 6, band 6p21.32 — a synonymous change in HLA-DQA1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Varicella zoster virus glycoproteins E and I antibody levels — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Varicella zoster virus glycoproteins E and I antibody levels.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Varicella zoster virus glycoproteins E and I antibody levels compared to the general population.
Source

Questions about rs1048381

What is rs1048381?

rs1048381 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with varicella zoster virus glycoproteins e and i antibody levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1048381 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1048381 come from?

GWAS Catalog, Open Forum Infect Dis 2020, PMID:33204752. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Varicella zoster virus glycoproteins E and I antibody levels (rs1048381). MyGeneLog™. https://www.mygenelog.com/variants/rs1048381

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