Standard

Glycated hemoglobin levels

FN3K · rs1046875

Where this position leads

Condition: Type 2 Diabetes

rs1046875 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs1046875 rs1046875 FN3K

What the study found

Who was studied 17,290 East Asian ancestry individuals, 1,727 Malay ancestry individuals; replicated in up to 13,585 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.08 higher (95% confidence interval 0.060-0.100); p = 4 × 10−17.

How common The A allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 17, band 17q25.3 — in the 3′ untranslated region of FN3KRP.

What each result means

A/A Two copies of the version the research linked to Glycated hemoglobin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Glycated hemoglobin levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Glycated hemoglobin levels. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1046875

What is rs1046875?

rs1046875 is a single position in the genome, in or near the FN3K gene. Published research associates it with glycated hemoglobin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1046875 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1046875?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1046875 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1046875 come from?

GWAS Catalog, Diabetes 2014, PMID:24647736. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glycated hemoglobin levels (rs1046875). MyGeneLog™. https://www.mygenelog.com/variants/rs1046875

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