Who was studied 36,227 East Asian ancestry individuals; replicated in 57,699 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.062 lower (95% confidence interval 0.05-0.074); p = 8 × 10−39.
How common The A allele had a frequency of about 51% in the people studied.
Where it sits Chromosome 2, band 2q37.1 — between genes, 10.6 kb from DIS3L2.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Height compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Height.
G/GPublished research associates this genotype with typical/baseline likelihood of Height — no copies of the reported risk allele.
rs10460436 is a single position in the genome, in or near the NPPC gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10460436 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs10460436 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10460436 come from?
GWAS Catalog, Human molecular genetics 2015, PMID:25429064. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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