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Who was studied 286,581 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.416 higher (95% confidence interval 0.32-0.52); p = 4 × 10−10.
Where it sits Chromosome 11, band 11p11.2 — in an intron of NUP160.
What each result means
A/ATwo copies of the version the research linked to Systolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Systolic blood pressure. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Systolic blood pressure. This is the starting point the study compared everyone against.
Scientific reports · 2024 · PMID 39548300 · open access
Questions about rs10458914
What is rs10458914?
rs10458914 is a single position in the genome, in or near the NUP160 gene. Published research associates it with systolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10458914 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs10458914 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10458914 come from?
GWAS Catalog, Scientific reports 2024, PMID:39548300. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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