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CD109 antigen levels

CD109 · rs10455097

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻⁴⁶, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.603 higher (95% confidence interval 0.52-0.68); p = 3 × 10⁻⁴⁶.

Where it sits Chromosome 6, band 6q13 — a missense change in CD109.

What each result means

A/A No copy of the version the research linked to CD109 antigen levels. This is the starting point the study compared everyone against.

A/C One copy of the version the research linked to CD109 antigen levels. That is a smaller link than two copies.

C/C Two copies of the version the research linked to CD109 antigen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Connecting genetic risk to disease end points through the human blood plasma proteome

Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M

and 12 more — show all

Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J

Nature communications · 2017 · PMID 28240269 · open access

Questions about rs10455097

What is rs10455097?

rs10455097 is a single position in the genome, in or near the CD109 gene. Published research associates it with cd109 antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10455097 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10455097 come from?

GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

CD109 antigen levels (rs10455097). MyGeneLog™. https://www.mygenelog.com/variants/rs10455097

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