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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 542,901 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0886 lower (95% confidence interval 0.062-0.115); p = 7 × 10−11.
How common The C allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in an intron of MAPT-AS1.
What each result means
C/CTwo copies of the version the research linked to Age at first birth. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Age at first birth. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Age at first birth. This is the starting point the study compared everyone against.
Nature human behaviour · 2021 · PMID 34211149 · open access
Questions about rs10445366
What is rs10445366?
rs10445366 is a single position in the genome, in or near the MAPT-AS1 gene. Published research associates it with age at first birth. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10445366 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10445366 come from?
GWAS Catalog, Nature human behaviour 2021, PMID:34211149. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Age at first birth (rs10445366). MyGeneLog™. https://www.mygenelog.com/variants/rs10445366