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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 5,582 European ancestry cases, 32,476 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.152 higher (95% confidence interval 0.099-0.205); p = 2 × 10−8.
How common The T allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 14, band 14q12 — in an intron of COCH.
What each result means
C/CNo copy of the version the research linked to Esophageal adenocarcinoma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Esophageal adenocarcinoma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Esophageal adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs10431648 is a single position in the genome, in or near the COCH gene. Published research associates it with esophageal adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10431648 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10431648 come from?
GWAS Catalog, Gut 2023, PMID:35882562. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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