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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 61,745 African ancestry individuals, 6,967 Asian ancestry individuals, 297,166 European ancestry individuals, 26,644 Hispanic or Latin American individuals.
The effect
Each copy of the A allele shifted the measure 0.0118 lower (95% confidence interval 0.008-0.0156); p = 1 × 10−9.
Where it sits Chromosome 19, band 19p13.11 — in an intron of MYO9B.
What each result means
A/ATwo copies of the version the research linked to Prostate-specific antigen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Prostate-specific antigen levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Prostate-specific antigen levels. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39930085 · open access
Questions about rs10408887
What is rs10408887?
rs10408887 is a single position in the genome, in or near the MYO9B gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs10408887 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10408887 come from?
GWAS Catalog, Nature genetics 2025, PMID:39930085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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