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Atopic dermatitis

near ACTL9 · rs10406865

Where this position leads

Condition: Atopic Dermatitis

rs10406865 Condition: Atopic Dermatitis Atopic Dermatitis Condition rs10406865 rs10406865 near ACTL9

What the study found

Who was studied 33,262 European ancestry cases, 804,234 European ancestry controls; replicated in 7,267 East Asian ancestry cases, 219,529 East Asian ancestry controls, 2,785 African American or Afro-Caribbean cases, 3,933 African American or Afro-Caribbean controls.

The effect Each copy of the T allele shifted the measure 0.0601 lower (95% confidence interval 0.039-0.082); p = 4 × 10−8.

Where it sits Chromosome 19, band 19p13.2 — between genes, 9.7 kb from ACTL9.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Atopic dermatitis — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Atopic dermatitis.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Atopic dermatitis compared to the general population.
Source
Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis
Chen Y, Chen W
The Journal of investigative dermatology · 2022 · PMID 35577104

Questions about rs10406865

What is rs10406865?

rs10406865 is a single position in the genome, in or near the near ACTL9 gene. Published research associates it with atopic dermatitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10406865 linked to?

On MyGeneLog this position is linked to Atopic Dermatitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs10406865 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10406865 come from?

GWAS Catalog, The Journal of investigative dermatology 2022, PMID:35577104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atopic dermatitis (rs10406865). MyGeneLog™. https://www.mygenelog.com/variants/rs10406865

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