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Who was studied 19,149 European ancestry cases, 680,049 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.07 lower (95% confidence interval 0.05-0.09); p = 7 × 10−9.
How common The A allele had a frequency of about 36% in the people studied.
Where it sits Chromosome 1, band 1q21.3 — in an intron of CTXND2.
What each result means
A/ATwo copies of the version the research linked to Cutaneous squamous cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cutaneous squamous cell carcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cutaneous squamous cell carcinoma. This is the starting point the study compared everyone against.
Nature communications · 2020 · PMID 32041948 · open access
Questions about rs10399947
What is rs10399947?
rs10399947 is a single position in the genome, in or near the ARNT gene. Published research associates it with cutaneous squamous cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10399947 linked to?
On MyGeneLog this position is linked to Cutaneous Squamous Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs10399947 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10399947 come from?
GWAS Catalog, Nature communications 2020, PMID:32041948. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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