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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 3,230 European ancestry cases, 475,964 European ancestry controls, 1,155 East Asian ancestry cases, 173,601 East Asian ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.289 higher (95% confidence interval 0.2-0.38); p = 9 × 10−10.
Where it sits Chromosome 15, band 15q21.1 — in an intron of FBN1.
What each result means
C/CTwo copies of the version the research linked to Aortic aneurysm. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Aortic aneurysm. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Aortic aneurysm. This is the starting point the study compared everyone against.
rs1036476 is a single position in the genome, in or near the FBN1 gene. Published research associates it with aortic aneurysm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1036476 linked to?
On MyGeneLog this position is linked to Abdominal Aortic Aneurysm. The research behind each link, and its sources, are set out on that condition page.
Does having rs1036476 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1036476 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 911124Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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