Sensitive

Colorectal cancer

GREM1 · rs10318

Where this position leads

What the study found

Who was studied 15,714 European ancestry cases, 621,182 European ancestry controls, 7,062 East Asian ancestry cases, 195,745 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0877 higher; p = 3 × 10⁻²⁰.

Where it sits Chromosome 15, band 15q13.3 — in the 3′ untranslated region of GREM1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Colorectal cancer — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Colorectal cancer.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Colorectal cancer compared to the general population.

Source

Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies

Tian J, Zhang M, Zhang F, Gao K, Lu Z, Cai Y, Chen C, Ning C, Li Y, Qian S, Bai H, Liu Y

and 10 more — show all

Zhang H, Chen S, Li X, Wei Y, Li B, Zhu Y, Yang J, Jin M, Miao X, Chen K

Genome medicine · 2024 · PMID 38872215 · open access

Questions about rs10318

What is rs10318?

rs10318 is a single position in the genome, in or near the GREM1 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10318 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs10318 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10318 come from?

GWAS Catalog, Genome medicine 2024, PMID:38872215. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Colorectal cancer (rs10318). MyGeneLog™. https://www.mygenelog.com/variants/rs10318

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