Who was studied 17,894 European ancestry cases, 325,132 European ancestry controls, 18,833 East Asian ancestry cases, 146,214 East Asian ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.0942 higher (95% confidence interval 0.074-0.114); p = 2 × 10−20.
Where it sits Chromosome 4, band 4q31.22 — between genes, 1.8 kb from EDNRA.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Stable angina pectoris compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Stable angina pectoris.
T/TPublished research associates this genotype with typical/baseline likelihood of Stable angina pectoris — no copies of the reported risk allele.
rs10305838 is a single position in the genome, in or near the near EDNRA gene. Published research associates it with stable angina pectoris. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10305838 linked to?
On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.
Does having rs10305838 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10305838 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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