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Rheumatoid arthritis

FIS1 · rs10275421

Where this position leads

Condition: Rheumatoid Arthritis

rs10275421 Condition: Rheumatoid Arthritis Rheumatoid Arthritis Condition rs10275421 rs10275421 FIS1

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Rheumatoid arthritis — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Rheumatoid arthritis.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Rheumatoid arthritis compared to the general population.
Source
Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset
Saad MN, Mabrouk MS, Eldeib AM, Shaker OG
Journal of advanced research · 2019 · PMID 30891314 · open access

Questions about rs10275421

What is rs10275421?

rs10275421 is a single position in the genome, in or near the FIS1 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10275421 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs10275421 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10275421 come from?

GWAS Catalog, J Adv Res 2019, PMID:30891314. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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