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Eosinophil percentage of granulocytes

ANKRD33B · rs1026914

Where this position leads

Condition: Blood Cell Counts

rs1026914 Condition: Blood Cell Counts Blood Cell Counts Condition rs1026914 rs1026914 ANKRD33B

What the study found

Who was studied 170,536 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0256 higher (95% confidence interval 0.017-0.034); p = 2 × 10−9.

How common The G allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 5, band 5p15.2 — in an intron of ANKRD33B.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Eosinophil percentage of granulocytes — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Eosinophil percentage of granulocytes.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Eosinophil percentage of granulocytes compared to the general population.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S
and 62 more — show all
Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K, Garner SF, Grassi L, Guerrero J, Haimel M, Janssen-Megens EM, Kaan A, Kamat M, Kim B, Mandoli A, Marchini J, Martens JHA, Meacham S, Megy K, O'Connell J, Petersen R, Sharifi N, Sheard SM, Staley JR, Tuna S, van der Ent M, Walter K, Wang SY, Wheeler E, Wilder SP, Iotchkova V, Moore C, Sambrook J, Stunnenberg HG, Di Angelantonio E, Kaptoge S, Kuijpers TW, Carrillo-de-Santa-Pau E, Juan D, Rico D, Valencia A, Chen L, Ge B, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yang Y, Guigo R, Beck S, Paul DS, Pastinen T, Bujold D, Bourque G, Frontini M, Danesh J, Roberts DJ, Ouwehand WH, Butterworth AS, Soranzo N
Cell · 2016 · PMID 27863252 · open access

Questions about rs1026914

What is rs1026914?

rs1026914 is a single position in the genome, in or near the ANKRD33B gene. Published research associates it with eosinophil percentage of granulocytes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1026914 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs1026914 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1026914 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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