Sensitive

Restless legs syndrome

MAP2K5 · rs1026732

Where this position leads

Condition: Restless Legs Syndrome

rs1026732 Condition: Restless Legs Syndrome Restless Legs Syndrome Condition rs1026732 rs1026732 MAP2K5

What the study found

Who was studied 3,652 European ancestry cases, 5,360 European ancestry controls.

The effect Each copy of the G allele carried 1.42 times the odds of Restless legs syndrome (95% confidence interval 1.32-1.53); p = 2 × 10−19.

Where it sits Chromosome 15, band 15q23 — in an intron of MAP2K5.

What each result means

A/A No copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1026732

What is rs1026732?

rs1026732 is a single position in the genome, in or near the MAP2K5 gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1026732 linked to?

On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs1026732 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1026732 come from?

GWAS Catalog, Sleep medicine 2022, PMID:35489115. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Restless legs syndrome (rs1026732). MyGeneLog™. https://www.mygenelog.com/variants/rs1026732

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