Sensitive

Rheumatoid arthritis

IKZF1 · rs10261758

Where this position leads

Condition: Rheumatoid Arthritis

What the study found

Who was studied 26,612 European ancestry cases, 869,454 European ancestry controls, 4,701 cases, 125,923 controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 4 × 10⁻¹².

How common The G allele had a frequency of about 29% in the people studied.

Where it sits Chromosome 7, band 7p12.2 — in an intron of IKZF1.

What each result means

A/A No copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Saevarsdottir S, Stefansdottir L, Sulem P, Thorleifsson G, Ferkingstad E, Rutsdottir G, Glintborg B, Westerlind H, Grondal G, Loft IC, Sorensen SB, Lie BA

and 66 more — show all

Brink M, Ärlestig L, Arnthorsson AO, Baecklund E, Banasik K, Bank S, Bjorkman LI, Ellingsen T, Erikstrup C, Frei O, Gjertsson I, Gudbjartsson DF, Gudjonsson SA, Halldorsson GH, Hendricks O, Hillert J, Hogdall E, Jacobsen S, Jensen DV, Jonsson H, Kastbom A, Kockum I, Kristensen S, Kristjansdottir H, Larsen MH, Linauskas A, Hauge EM, Loft AG, Ludviksson BR, Lund SH, Markusson T, Masson G, Melsted P, Moore KHS, Munk H, Nielsen KR, Norddahl GL, Oddsson A, Olafsdottir TA, Olason PI, Olsson T, Ostrowski SR, Hørslev-Petersen K, Rognvaldsson S, Sanner H, Silberberg GN, Stefansson H, Sørensen E, Sørensen IJ, Turesson C, Bergman T, Alfredsson L, Kvien TK, Brunak S, Steinsson K, Andersen V, Andreassen OA, Rantapää-Dahlqvist S, Hetland ML, Klareskog L, Askling J, Padyukov L, Pedersen OB, Thorsteinsdottir U, Jonsdottir I, Stefansson K

Members of the DBDS Genomic Consortium · Danish RA Genetics Working Group · Swedish Rheumatology Quality Register Biobank Study Group (SRQb)

Annals of the rheumatic diseases · 2022 · PMID 35470158 · open access

Questions about rs10261758

What is rs10261758?

rs10261758 is a single position in the genome, in or near the IKZF1 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10261758 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs10261758 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10261758 come from?

GWAS Catalog, Annals of the rheumatic diseases 2022, PMID:35470158. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Rheumatoid arthritis (rs10261758). MyGeneLog™. https://www.mygenelog.com/variants/rs10261758

← See all variants