GCK · rs10259649
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 2,267 Qatari ancestry cases, 8,665 Qatari ancestry controls.
The effect Each copy of the C allele carried 1.24 times the odds of Prediabetes (95% confidence interval 1.14-1.34); p = 3 × 10−8.
How common The C allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 7, band 7p13 — in an intron of GCK.
rs10259649 is a single position in the genome, in or near the GCK gene. Published research associates it with prediabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Diabetes, obesity & metabolism 2025, PMID:40468860. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Prediabetes (rs10259649). MyGeneLog™. https://www.mygenelog.com/variants/rs10259649